Charles Phillips

Charles Phillips, PhD

Principal Solution Scientist | Scientific AI & ML • Multimodal Data • Computational Chemistry

Professional Summary

Scientist and ML practitioner bridging computational biophysics, software engineering, and enterprise life-sciences delivery. PhD-trained in multiscale chromatin modelling at the University of Cambridge, with peer-reviewed research featured on the cover of Science Advances (2026).

At Intellegens (May 2024–present), I have progressed from lead scientific developer of the Alchemite™ Oligonucleotide solution through product leadership to my current role as Principal Solution Scientist-the technical and scientific lead for customer engagements across materials, chemicals, and life sciences.

I design multi-modal data pipelines across diverse experimental sources and vendor platforms, integrate bespoke processing into Alchemite™ modelling workflows, and deploy automated strategies for data-quality and integration issues during trials and pilots. I regularly deliver live technical demonstrations to global scientific audiences and work with development and commercial teams to turn high-potential proof-of-concept work into scalable product features.

Earlier at Intellegens, I led the Alchemite™ Oligonucleotide programme from concept to adoption by major industry partners - work that contributed to Intellegens being named a finalist for Life Science Company of the Year at the 2026 Cambridge Independent Science & Technology Awards. I combine this delivery experience with PhD-level computational chemistry and hands-on ML engineering (Python, C++, molecular simulation).

Core Expertise

Machine Learning & Data Science
Sparse / high-dimensional experimental data · Gaussian processes & ensemble methods · Image analysis pipelines for biology · Feature engineering · Model validation & leakage-aware workflows · Alchemite™ platform extensions
Life Sciences, Chemistry & Computational Biophysics
Oligonucleotide therapeutics (ASO, siRNA) · Solid-phase synthesis impurities · Chromatin & epigenetics · Pharma R&D workflows · Polymer science · Formulation-adjacent analytical data · Coarse-grained molecular dynamics · LAMMPS · Enhanced sampling · Chromatin phase behaviour · DNA–protein electrostatics · Free-energy methods · Scientific software in Python & C++
Technical Stack
Python (NumPy, Pandas, scikit-learn, PyTorch ecosystem) · C++ · LAMMPS · Git · Docker · Data pipelines for multi-modal lab datasets · Technical writing & interactive tooling (web visualisations)
Delivery & Communication
Principal solution scientist engagements · Multi-modal pipeline design · Customer trials & pilots · PoC-to-product collaboration · Live demos & training · Cross-functional work with development and commercial teams

Professional Experience

Principal Solution Scientist

Intellegens · Cambridge, UK · February 2026 – Present

Technical and scientific lead for customer engagements - delivering bespoke computational solutions and automation frameworks tailored to custom infrastructure and research workflows.

  • Design and implement multi-modal data pipelines across experimental sources and vendor platforms, integrating custom processing into Alchemite™ modelling workflows
  • Develop and deploy automated detection and mitigation for customer-specific data quality and integration issues through trials and pilot assessments
  • Deliver live technical demonstrations globally, translating ML architectures and outputs into insights aligned with customer research objectives
  • Identify proof-of-concept extensions with market potential and collaborate with development and commercial teams to scale them into product features
  • Drive platform performance improvements and expansion opportunities with named accounts across materials, chemicals, and life sciences

Technical highlights: Multi-modal pipelines · Alchemite™ integration · Solution architecture · Enterprise scientific delivery

Principal Life Science Innovation Lead

Intellegens · Cambridge, UK · October 2025 – February 2026

Led strategic direction and delivery of the Alchemite™ Oligonucleotide software solution - full conceptualization-to-deployment lifecycle with scalable workflows aligned to industrial requirements.

  • Coordinated technical and commercial leadership to drive rapid market adoption and secure adoption by major industry partners
  • Supported customer teams from early-stage research through late-phase development
  • Alchemite™ Oligonucleotide programme contributed to Intellegens being named a finalist for Life Science Company of the Year (2026 Cambridge Independent Science & Technology Awards)

Technical highlights: Product strategy · Oligonucleotide manufacturing ML · Pharma & biotech partnerships · Go-to-market delivery

Machine Learning Scientist - R&D

Intellegens · Cambridge, UK · May 2024 – September 2025

Lead scientific and technical developer of the Alchemite™ solution for oligonucleotide manufacturing - end-to-end development from scientific strategy through technical implementation and project execution.

  • Directed development of ML solutions for biopharmaceutical R&D and manufacturing (synthesis, purification, analytics)
  • Drove end-to-end customer project support across diverse data types and domains including materials science, life sciences, and manufacturing
  • Contributed to core Alchemite™ platform innovation - robustness, scalability, and impact on complex, noisy experimental data
  • Co-authored and presented recorded webinar on accelerating oligonucleotide process development with ML

Technical highlights: Alchemite™ · Oligonucleotide SPOS · Active learning · High-dimensional sparse data · Customer R&D delivery

Doctoral Researcher - Theoretical & Computational Chemistry

University of Cambridge · Collepardo Research Group · October 2020 – February 2024

Member of Professor Rosana Collepardo-Guevara’s group, developing multi-scale computational models of genome structure and chromatin organisation at the nanoscale. Thesis: “Dissecting the Architectural Properties of Chromatin and the Influence of the H1 Linker Histone on Chromatin Regulation.”

Investigated how intrinsic nucleosome properties, epigenetic modifications, and architectural proteins regulate chromatin across functionally distinct domains - linking molecular detail (H1, nucleosomes, epigenetics) to mesoscale “liquid-like” organisation using the lab’s mechanistic multiscale chromatin model.

  • Extended chemically specific coarse-grained chromatin models (Python, C++, LAMMPS) for phase behaviour and linker histone H1 effects
  • Created custom enhanced-sampling methods; collaborated internationally with experimental groups
  • Computational work underpinning Science Advances (2026) front-cover paper on H1 as a liquid-like chromatin glue

Technical highlights: Multiscale chromatin MD · Phase separation · Epigenetics · Enhanced sampling · Scientific C++

MPhil in Scientific Computing

University of Cambridge · Department of Physics · 2019 – 2020

Thesis: “Computational Physics of Chromatin: Effects of DNA Linker Length on Liquid–Liquid Phase Separation of Chromatin.”

  • Distinction - short project: “Chromatin Compaction as a Function of Nucleosome Repeat Length”
  • Distinction - short project: “Mid-Resolution Coarse-Grained Model for Oligonucleotides”

Selected courses: C++ for Scientific Computing · Software Design · Data Visualisation · Atomistic Modelling of Materials · Electronic Structure & DFT · Introduction to Quantum Mechanics · Mesoscale Coarse-Grained Modelling

Research Assistant / Intern

Huntsman Corporation · Everberg, Belgium · August 2017 – August 2018

  • Polymer science research leading to granted patent WO2021175730A1
  • Developed synthesis routes and characterised materials (rheology, spectroscopy, mechanical testing)
  • Awarded the highest grade ever given to a research intern at the site

Publications & Thought Leadership

Selected highlights - not exhaustive.

Peer-reviewed, preprints & major research outputs
  • Shimazoe et al., “Linker histone H1 functions as a liquid-like glue to organize chromatin in living human cells” - Science Advances, 2026 (doi:10.1126/sciadv.aec9801) · write-up
  • Padroni et al., “The Potential of Machine Learning in Oligonucleotide Therapeutics Manufacturing” - ChemRxiv, 2025 (preprint) · doi
  • PhD thesis: chromatin architecture & H1 linker histone regulation - University of Cambridge, 2024
  • Patent WO2021175730A1 - polymer synthesis (Huntsman), 2021
Intellegens - oligonucleotides & scientific AI
Technical writing & demos (this site)
Events - speaking, panels, posters & training

EuroTIDES

Basel, Switzerland · November 2025

  • My project work was featured in two talks at the conference

Speaker · AI × Therapeutics

Stevenage, UK · September 2025

  • Presented the Intellegens oligonucleotide software solution
  • Engaged with attendees and set up demos with companies at the event

Panel Member · CHEM UK - AI and Digital Tools

London, UK · May 2025

  • Cross-disciplinary panel on the impact of AI and digital tools on chemistry research
  • Shared experience as an ML scientist in life and chemical sciences; actionable recommendations for AI/ML in R&D and manufacturing workflows

Speaker · Acceleration of oligonucleotide process development via machine learning

Innovation in Oligonucleotide Manufacturing Symposium 2025 · Glasgow, UK · April 2025

  • Talk on leveraging machine learning to accelerate oligonucleotide manufacturing
  • Presented Intellegens work and the Alchemite™ Oligonucleotide platform developed for process development

Poster Presenter · 12th Annual Oligonucleotide Networking Event

AstraZeneca · Macclesfield, UK · March 2025

  • Poster: “A novel machine learning (ML)-driven tool to accelerate oligonucleotide process development”
  • Discussed manufacturing challenges and how advanced ML with automated experimental data preprocessing can address them

Lead Presenter · Intellegens Workshops

Online · June 2024 & April 2025

  • Delivered updates as technical lead and scientific developer of a predictive model for optimising oligonucleotide manufacturing
  • Presented to partners from major pharma companies with live technical demos
  • Led breakout discussions to explain the software and gather real-time partner feedback

Panel Member · Future Biotechnologists

Cambridge, UK · November 2024

  • Panel on the future of biotechnology and the role of computational methods for prospective undergraduates
  • Coordinated with academic staff to align the event with the target demographic
  • Led round-table discussions on career paths in biotechnology

Poster Presenter · Chromatin and Epigenetics

EMBL · Heidelberg, Germany · May 2023

  • Poster on chromatin arrangements and H1 linker histone effects in vivo and in vitro, using computational modelling

Education

PhD in Chemistry (Theoretical & Computational)

University of Cambridge · Collepardo Research Group · October 2020 – February 2024

Multi-scale computational investigation of chromatin organisation - from nucleosome-level interactions and epigenetic modifications to mesoscale liquid-like behaviour and H1 linker histone regulation.

  • Thesis: “Dissecting the Architectural Properties of Chromatin and the Influence of the H1 Linker Histone on Chromatin Regulation.”
  • Supervisor: Professor Rosana Collepardo-Guevara (Chemistry, Physics & Genetics)

MPhil in Scientific Computing

University of Cambridge, Department of Physics · 2019 – 2020

  • Thesis: “Computational Physics of Chromatin: Effects of DNA Linker Length on Liquid–Liquid Phase Separation of Chromatin.”
  • Distinction - “Chromatin Compaction as a Function of Nucleosome Repeat Length”
  • Distinction - “Mid-Resolution Coarse-Grained Model for Oligonucleotides”
MPhil courses
C++ for Scientific Computing · Software Design · Data Visualisation Techniques · Atomistic Modelling of Materials · Electronic Structure and DFT · Introduction to Quantum Mechanics · Mesoscale Coarse-Grained Modelling

MChem in Pure and Applied Chemistry

University of Strathclyde · September 2014 – September 2019

  • Undergraduate thesis: DNA double-helix stability via molecular dynamics & free-energy methods
Strathclyde skills & competencies
Chemistry Computational Chemistry Molecular Dynamics Biomolecular Simulation Statistical Mechanics Thermodynamics Organic & Inorganic Synthesis Analytical Chemistry Forensic Chemistry Data Analysis Scientific Writing Problem Solving

Beyond Work

Rowing - Won a rowing blade for Queens' College, Cambridge in May Bumps (M1, first division), beating St John's, Robinson, Jesus, and Trinity Cambridge colleges
Music - Actively play in bands; competed in Young Musician of the Year (2013 & 2014) for classical guitar; play seven instruments
Hobbies - MMA, climbing, wild swimming, and hiking